FlowSynth:
Continuous Flow Reaction System

More and more, today's organic chemists are discovering the advantages of controlled microwaves as a heat source for synthetic reactions, across the pharmaceutical, biotech, polymers and plastics, and fine and agro chemicals industries. Microwave synthesis is already the state-of-the-art technology for exploratory and parallel synthesis. As a result, there is growing demand for the ability to scale up synthetic reactions in the microwave from grams to kilograms.

To address those needs, Milestone, an acknowledged leader in scalability of microwave reactions, has developed the new FlowSynth system. This continuous-flow microwave reactor represents the link between laboratory-scale reactions and industrial-scale synthetic production. When you are ready to scale up your microwave-enhanced chemistry to kilogram quantities, Milestone will be ready to support you with a FlowSynth labstation configured to your needs.

What you learn in the multimode cavity of the bench-top MicroSYNTH labstation will be easily transferable to the FlowSynth, which uses a flow-through reaction scheme with full control over all reaction parameters, including the residence time of the chemistry in the microwave field.

• Scale Up from Grams to Kilograms
• Purity of Reaction Products
  Fast heating & cooling minimizes reaction by-products
• Rapid Throughput
  Flow rate adjustable from 5 to 300 ml/min
• Easy to Operate
  Intuitive software control, thorough documentation, and easy-to-access reagent reservoirs make operation simple
• Full temperature and pressure control
  Run reactions at temperatures up to 200¼C, and pressures up to 280 psi, with precise monitoring & control of process conditions
• Compatible with MicroSYNTH instrumentation
  Reactions optimized in Milestone's MicroSYNTH labstation can be easily adapted to run in the FlowSynth
• Unsurpassed Operator Safety
  Safety Officers worldwide encourage their chemists to choose Milestone equipment

The System
The FlowSynth system consists of a microwave labstation fitted with a vertical reactor. Reagents are pumped in from the bottom of the reactor, and the reaction products flow out the top into a water-cooled heat exchanger. In-line sensors allow continuous monitoring of the reaction temperature. Homogeneity of temperature along the entire length of the reactor is ensured by a unique rotating microwave diffuser.

Full Process Control
The FlowSynth system is controlled by an external touchscreen control terminal. Intuitive software allows the user to control everything from process conditions (temperature, pressure, etc.) to hardware operating parameters (pump speed, back pressure valve, and safety operating limits).

The user simply defines the desired temperature-vs.-time profile, and the FlowSynth will automatically carry out the programmed cycle, monitoring the process conditions to ensure precise, repeatable adherence to the given method.

A high-performance polymer shield and a computer-controlled pressure control valve help to ensure safe conditions in the TFM flow-through vessel at all times.

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