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Introduced March 2006
Multimode Heating
While monomode format can be useful for optimizing a single reaction, multimode format provides an entirely different level of flexibility. Chemists can run larger volume reactions, or multiple identical reactions simultaneously.
In multimode format, a carousel of reaction vials rotates in the microwave cavity. The MultiSYNTH is configured to deliver a microwave field of uniform intensity throughout the chamber. All vials are exposed to the same heating conditions, so reactions can be run in parallel with complete reproducibility.
Small-Volume Parallel Synthesis
The MultiSYNTH labstation offers effortless scalability. Once the reaction conditions have been optimized, a reaction can be moved into the multimode configuration, utilizing the same experimental parameters developed on a single reaction. The MultiSYNTH allows the chemist to run up to 12 reactions simultaneously for true parallel synthesis.
As with all reactions in the MultiSYNTH, reproducible reaction conditions are ensured with internal fiber-optic temperature control, vortex agitation, and external infrared temperature monitoring of all vials.
Large-Volume Synthesis
Utilizing previously developed time and temperature profiles, syntheses can easily be scaled up to produce larger amounts of product and to accommodate reaction volues up to 40 mL. The system can also accommodate a large batch reflux reactor up to 1 liter in volume.
In addition to running small-scale parallel reactions, the MultiSYNTH has the ability to run up to 6 x 40 mL reactions simultaneously without additional method development. This allows the chemist to perform six reactions using different reagents and substituents, or run six of the same reaction to combine and further increase the amount of material produced.
With little or no additional method development, reactions optimized in the MultiSYNTH can be further scaled up to the larger batch and flow-through members of Milestone's family of synthesis instruments.
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