MultiSYNTH Labstation

Introduced March 2006

Single-Mode Heating

In single-mode format, a standing waveform is created. A single vessel is placed in the dedicated single-mode position within the labstation cavity—the "sweet spot" where the microwave energy intensity is highest. This position is optimized for fast heating and cooling. For many chemists, this monomode setup is the preferred format for optimizing a single reaction under predictable microwave intensity.

Using disposable glass reaction vials, the MultiSYNTH allows the medicinal chemist to quickly synthesize compounds with reaction volumes from 0.2–6.0 mL. Reproducibile reactions are ensured with external infrared temperature control or internal fiber-optic probe.

Reaction Efficiency

Flash Heating

With a generous 800 watts of microwave power, the MultiSYNTH offers "flash" heating capabilities, to help the chemist work faster and minimize the time a reaction spends at temperatures other than the target temperature. For example, 3 mL of ethanol can be heated to 150°C in just 40 seconds.

Fast Cooling

In microwave synthesis, rapid cooling is as important as rapid heating. The MultiSYNTH uses directed air flow to achieve fast cooling of the reactants. Fast cooling leads to enhanced yields during the run, and reaction quenching at the end of the run, minimizing undesired side reactions and improving reaction purity.

Improving the Monomode Experience

Reaction Agitation

In traditional single-mode systems, the reaction vial is located inside a microwave waveguide. The position of the vial is very critical, as the microwave intensity varies from 0 to 100% within a width of 30 mm. Temperature may be uneven, particularly for larger-scale reactions.

With the MultiSYNTH, this inherent limitation of single-mode units is overcome by a unique "vortex agitation" feature. The vial is mechanically shaken during the course of the reaction to prevent hot and cold spots from forming. This technique serves to ensure reaction homogeneity and eliminate shattered reaction vials.

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