The RotoSYNTH offers the most advanced application versatility as shown in the images below:

Typical RotoSYNTH applications

»»  Solid phase synthesis, with or without solvent (dry media)
»»  Synthesis of inorganic materials
»»  Surface functionalization of glass and polymer beads
»»  Polymerization reactions under vacuum (Polycondensations)
»»  Dehydration of natural oils
»»  Coating of polymeric membranes
»»  Impregnation and functionalization of drug carriers
»»  Synthesis, Functionalization, and Surface Treatment of Nanoparticles
»»  Large scale homogeneous phase reactions without ‘hot spots’
»»  Reactions under vacuum and protective or reactive atmosphere
»»  Drying of raw organic, inorganic, and polymeric materials
»»  Synthesis of biofuels
»»  Extraction of volatile active compounds

Esterification reaction

Using the Milestone RotoSYNTH, water is continuously removed from the reaction mixture, shifting the equilibrium toward the ester formation and improving the reaction yield.

K.M. Amore, N.E. Leadbeater, Macromolecular Rapid Communication, 28, 2007, 473.
 

Formation of crystalline Nanoparticles

Due to the unique rotative stirring and to the highly homogeneous and fast heating, the nanoparticles crystallization is almost instantaneous, resulting in anhydrous oxide materials with low defect concentration.

Microwave promoted synthesis of LaPO4: Ce; IL: [N(t-Bu)₃(Me)][N(SO₂CF₃)₂]
G. Buhler, M. Stay. C. Feldmann, Green Chemistry, 9, 2007, 924.