FlowSYNTH:
Continuous Flow Reaction System

Introduced March 2006

The new FlowSYNTH system is a continuous flow microwave reactor that represents the link between laboratory-scale reactions and industrial-scale synthetic production. This revolutionary system allows chemists to scale up reactions from grams to kilogram quantities.

What you learn in the multimode cavity of the bench-top MultiSYNTH or MicroSYNTH labstation will be easily transferable to the FlowSYNTH, which uses a flow-through reaction scheme with full control over all reaction parameters, including the residence time of the chemistry in the microwave field.

• Scale Up from Grams to Kilograms
• Purity of Reaction Products
  Fast heating & cooling minimizes reaction by-products
• Adaptable to Your Chemistry
  Flow rate adjustable from 12 to 100 ml/min
• Easy to Operate
  Intuitive software control, thorough documentation, and easy-to-access reagent reservoirs make operation simple
• Full temperature and pressure control
  Run reactions at temperatures up to 200¼C, and pressures up to 30 bar, with precise monitoring & control of process conditions
• Compatible with smaller-scale instrumentation
  Reactions optimized in Milestone's MultiSYNTH or MicroSYNTH labstations can be easily adapted to run in the FlowSYNTH
• Unsurpassed Operator Safety
  Safety Officers worldwide encourage their chemists to choose Milestone equipment

The System
The FlowSYNTH system consists of a microwave labstation fitted with a vertical reactor. Reagents are pumped in from the bottom of the reactor, and the reaction products flow out the top into a water-cooled heat exchanger. In-line sensors allow continuous monitoring of the reaction temperature. Homogeneity of temperature along the entire length of the reactor is ensured by a unique screw-type solution homogenizer.

Full Process Control
The FlowSYNTH system is controlled by an external touch-screen control terminal. Intuitive software allows the user to control everything from process conditions (temperature, pressure, etc.) to hardware operating parameters (pump speed, back pressure valve, and safety operating limits).

The user simply defines the desired temperature-vs.-time profile, and the FlowSYNTH will automatically carry out the programmed cycle, monitoring the process conditions to ensure precise, repeatable adherence to the given method.

A high-performance polymer shield and a computer-controlled pressure control valve help to ensure safe conditions in the TFM flow-through vessel at all times.

In addition to the continuous flow configuration, this dedicated scale-up labstation can be fitted with a vertically mounted high-pressure batch reactor for large-volume applications. This configuration is available in combination with the FlowSYNTH configuration, or as a stand-alone option.

For details about the BatchSYNTH configuration, click here.

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